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Interestingly, the most striking respiratory difference attributable to loss of GSH emerged upon treatment of Gclc fl/fl and Gclc fl/fl Mb1-Cre + FoB with the mitochondrial ionophore FCCP, which increases the OCR to the maximal respiration (i.e
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The genomic effects of estrogen include the hormone binding to intracellular ERs, which then move to the nucleus and interact with the EREs on the DNA and alter the transcription of the genes that are involved in cell proliferation, apoptosis, and metabolic activities
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