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As skin ages, it gradually loses collagen and elasticity, causing its texture and structure to change and affecting how tattoos appear over time. At the same time, immune cells called macrophages interact

Underlying the epithelial layer is the lamina propria, which contains immune cells such as macrophages, dendritic cells, and lymphocytes, as well as structures like Peyer’s patches

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This is a preview of subscription content, access via your institution Access options Subscribe to this journal Receive 12 print issues and online access $259.00 per year only $21.58 per issue Rent or buy this article Prices vary by article type from$1.95 to$39.95 Prices may be subject to local taxes which are calculated during checkout Similar content being viewed by others References Blumenthal, S