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Screening may be warranted in patients with one or more risk factors, such as gastric or small intestine resections, inflammatory bowel disease, use of metformin for more than four months, use of proton pump inhibitors or histamine H 2 blockers for more than 12 months, vegans or strict vegetarians, and adults older than 75 years

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This has been documented in human clinical trials, in which people taking ME-3 orally for several weeks exhibit a 26% increase in total antioxidant activity.⁸ In summary, Lactobacillus fermentum ME-3 has been shown to have the highest Total Antioxidant Activity (TAA) and the highest Total Antioxidant Status (TAS) of any probiotic tested to date.⁹ 3) Supports cardiovascular health: Lactobacillus fermentum ME-3 has been shown to lower triglycerides and increase levels of the “good” HDL-cholesterol