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Specifically, there were the liver and lung congestion with intralveolar hemorrhage and pyknotic hepatocyte nuclei, marked congestion in heart tissue, within myocardium and large coronary branches, hyaline tubular cylinders, cell degeneration of proximal and distal tubule with cytoplasmic vacuolization in kidney after both in short-term (15 min ligation time, and period thereafter) and in long-term (24 h, 48 h)

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Although the liver injury caused by Polygonum multiflorum has received attention, our previous studies have shown that the liver injury caused by Polygonum multiflorum is specific, and its main pharmacodynamic component, TSG, is safe and effective [271]